Neuregulin-1 Modulates Hippocampal Gamma Oscillations: Implications for Schizophrenia
نویسندگان
چکیده
منابع مشابه
Gamma oscillations and schizophrenia.
In the last 2 decades, it has become apparent that brain regions communicate by coordinating the firing of populations of neurons. When neurons synchronize their firing, their rhythmic input is reflected in the extracellular field potential as brain oscillations. Rhythmic brain activity in animals and humans can be recorded using noninvasive techniques such as electroencephalography (EEG) by pl...
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The neuregulin/ErbB signaling network is genetically associated with schizophrenia and modulates hippocampal γ oscillations--a type of neuronal network activity important for higher brain processes and altered in psychiatric disorders. Because neuregulin-1 (NRG-1) dramatically increases extracellular dopamine levels in the hippocampus, we investigated the relationship between NRG/ErbB and dopam...
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The neuregulin 1 (NRG1) gene has been the subject of considerable excitement within the psychiatric genetics literature since it was originally identified as a potential susceptibility locus for schizophrenia. Here we provide an update of our first meta-analysis of this association. Case-control and family-based genetic association studies of the NRG1 gene in healthy control groups and clinical...
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Although the hippocampus plays a crucial role in encoding and retrieval of contextually mediated episodic memories, considerable controversy surrounds the role of the hippocampus in short-term or working memory. To examine both hippocampal and neocortical contributions to working memory function, we recorded electrocorticographic activity from widespread cortical and subcortical sites as 20 neu...
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Ketamine, an N-methyl-D-aspartate (NMDA) receptor glutamatergic antagonist, has been studied as a model of schizophrenia when applied in subanesthetic doses. In EEG studies, ketamine affects sensory gating and alters the oscillatory characteristics of neuronal signals in a complex manner. We investigated the effects of ketamine on in vivo recordings from the CA3 region of mouse hippocampus refe...
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ژورنال
عنوان ژورنال: Cerebral Cortex
سال: 2008
ISSN: 1460-2199,1047-3211
DOI: 10.1093/cercor/bhn107